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Journal: eLife
Article Title: Circulating platelets modulate oligodendrocyte progenitor cell differentiation during remyelination
doi: 10.7554/eLife.91757
Figure Lengend Snippet: ( A ) LPC induced demyelinating lesions in spinal cord white matter of WT mice at 1, 3, 7, and 14 dpl, stained for platelets (CD41 + ). Scale bar 100 μm. ( B ) Quantification of CD41 + signal within the demyelinated lesion at 1 (n= 6 ), 3 (n= 5 ), 5 (n= 5 ), 7 (n= 6 ), 10 (n=4), and 14 dpl (n= 4 ), and in NAWM (n= 3 ). ( C ) Platelet staining (CD41 + ) in spinal cord white matter injected with PBS/DAPI. Scale bar 50 μm. ( D ) Upper left panel: localization of platelets within blood vessels (ColIV + ) and in close proximity with OPCs (Olig2 + ) at 5 dpl. Upper right panel: IMARIS 3D projection shows the spatial distribution of platelets. Scale bar 10 μm. Lower panels: magnification of the IMARIS projection showing platelet aggregation within the blood (left panel) and penetration into the parenchyma (right panel). Scale bars: 5 μm (left panel) and 7 μm (right panel). Data were analysed using a Kruskal Wallis test. Data represent the mean ± SD. ** p<0.01; ns (not significant), p>0.05.
Article Snippet: Antibody ,
Techniques: Staining, Injection
Journal: eLife
Article Title: Circulating platelets modulate oligodendrocyte progenitor cell differentiation during remyelination
doi: 10.7554/eLife.91757
Figure Lengend Snippet:
Article Snippet: Antibody ,
Techniques: In Vivo, In Vitro, Concentration Assay, Bioprocessing